Importantly, although we observed an overall increase in FoxP3 expression on CD8 T-cells in untreated HIV infection that could affect the relative proportions of FoxP3+ subsets reported in our study, we also observed clear differences between the expression of various markers on FoxP3+ CD8 T-cells versus total CD8 T-cells which suggest the particular dynamics of FoxP3+ CD8 T-cells during HIV infection (Supplementary Table 2). This evidence concerns the gene FOXP3 and HIV infectious disease.