The opposite dominant effect was confirmed for both TLR9 SNPs, with an increased incidence of high-level infection among homozygous or heterozygous carriers of the minor alleles of rs5743836 (48.1% [26/54] versus 32.2% [46/143]; P-value = 0.038) and rs352139 (41.3% [57/138] versus 25.4% [15/59]; P-value = 0.034). The gene discussed is TLR9; the disease is infection.