Specifically, mutations in basal keratins 5 and 14, the hemidesmosomal plakins BP230 (dystonin) and plectin, underlie different EBS subtypes, while JEB is due to mutations in genes encoding the transmembrane hemidesmosomal proteins BP180 (collagen XVII) and integrin α6β4 as well as the epithelial laminin-332 chains. Here, DST is linked to epidermolysis bullosa simplex.