This increase contrasts with the typical decrease in corneal nerve density seen in models of type 1 diabetes [16, 21, 36, 37], in a model of late type 2 diabetes resulting from feeding a high fat diet combined with a low dose of STZ to induce insulin resistance, impede insulin secretion, and produce marked hyperglycemia [38], and in diabetic humans [39]. This evidence concerns the gene INS and Hyperglycemia.