For the targeting of MICA and MICB in cancer patients, we generated anti-MICA and MICB antibodies, by immunizing mice with recombinant soluble human MICA-Fc recombinant protein or a range of human C1R cells negative for endogenous MICA and MICB expression and engineered to express MICA alleles (Table 1). This evidence concerns the gene MICA and cancer.