Fetuin-A has been widely studied in a variety of diseases including non-alcoholic fatty liver disease (23), diabetes (24), cardiovascular disease (25), sepsis (17, 18), periodontitis (26, 27), osteoarthritis (28), chronic kidney disease (29), inflammatory bowel disease (30), and encapsulating peritoneal sclerosis (31). The gene discussed is AHSG; the disease is metabolic dysfunction-associated steatotic liver disease.