Recent studies have shown the recurrent t (6;9) (q22–23; p23–24) translocation in salivary and breast ACC results in a novel gene fusion of the MYB proto-oncogene with the transcription factor gene NFIB, and this gene rearrangement has become the major oncogenic event in ACC (9, 10). Here, NFIB is linked to adrenal cortex carcinoma.