In the keyword cluster #0, except for rheumatoid arthritis, other frequently occurring keywords such as inflammation, C-reactive protein, tumor necrosis factor (TNF) alpha, interleukin-6 (IL-6), interleukin-1 (IL-1), oxidative stress, endothelial dysfunction, etc., indicated that this cluster mainly focused on the molecular mechanism and signal pathway of RA-related CVD. The gene discussed is IL6; the disease is endothelial dysfunction.