Additionally, the presence of liver fibrosis in all patients throughout a median period of 58.5 months was associated with higher plasma log10 HIV RNA, lower CD4 T cell counts, HIV-HBV co-infection irrespective on the presence/absence of HBsAg (for the APRI score) and non-adherence to ART (for the Fib-4 score). This evidence concerns the gene CD4 and coinfection.