Regarding the risk factors for liver fibrosis, it is expected that the cumulative exposure to ART leads to a gradual decline on the impact of various risk factors for liver fibrosis, In this respect, studies on patients undergoing ART show discordant data on various risk factors for liver fibrosis such as advancing age, male gender, detectable HIV RNA, lower CD4 T cell counts as well as the presence of HBV/HCV co-infection and detectable plasma HBV DNA (4, 16, 17, 33, 36, 39). Here, CD4 is linked to Hepatic fibrosis.