Promote over-expression of Nrf2, and promote proliferation of esophagus cancer cells; inhibit proliferation and metastasis of esophageal esophagus cancer cells; inhibit activity of HIF-1 and gene expression; phosphorylation of ERKl/2, cJNK and P38; up-regulate miR-142-3p via secreting microvesicles, and inhibit metastasis of liver cancer cells;. The gene discussed is HIF1A; the disease is esophageal cancer.