Etomidate contributed to the loss of mitochondrial membrane potential (MMP) in N2a cells; produced reactive oxygen species (ROS); promoted the generation of apoptin such as PARP, caspase-9, and procaspase3; and facilitated the apoptosis of neuroblastoma Neuro-2a cells (N2a) (64). This evidence concerns the gene CASP3 and neuroblastoma.