A report indicated that isoflurane upregulated the expression of HIF-1α in prostate cancer cells via the PI3K/AKT/mTOR signal pathway and contributed to the increased cell invasion and migration (42), but the use of propofol could reverse the activation of the signaling pathway involved, which indicated its application value in the operation of patients with tumors. Here, HIF1A is linked to Familial prostate cancer.