This study also reported that naive B cells, plasma cells, activated/resting NK cells, M0 macrophages, M1 macrophages, resting CD4+ T memory cells, resting mast cells, memory B cells, and resting/activated DCs are likely to critically impact the occurrence and progress of AD, which may serve as potential targets for future immunotherapy in patients with AD that warrant in-depth explorations. Here, CD4 is linked to Alzheimer disease.