The results revealed higher proportions of naive B cells, plasma cells, activated NK cells, M0 macrophages, M1 macrophages, resting CD4+ memory cells, and resting mast cells in the AD group, along with lower proportions of memory B cells, resting NK cells, resting/activated DCs, and eosinophils (Figure 7A), suggesting these cells may be related to the occurrence and progression of AD. Here, CD4 is linked to Alzheimer disease.