CD4 and Alzheimer disease: In comparison with normal samples, AD samples generally contained a higher proportion of naive B cells (p = 0.034), plasma cells (p = 0.002), resting memory CD4+ T cells (p < 0.001), activated NK cells (p < 0.001), M0 macrophages (p = 0.011), M1 macrophages (p = 0.019), and resting Mast cells (p < 0.001), whereas the proportions of memory B cells (p < 0.001), resting NK cells (p < 0.001), resting DCs (p < 0.001), activated DCs (p = 0.003), and eosinophils (p = 0.002) were relatively lower (Figure 7A).