As shown in Figure 6A, the feature biomarkers demonstrated a high diagnostic power in discriminating AD brains from the control samples, with an AUC of 0.800 (95% CI 0.744–0.855) in MAFF, AUC of 0.777 (95% CI 0.714–0.839) in ADCYAP1, AUC of 0.796 (95% CI 0.736–0.849) in ZFP36L1, When the three genes were combined into one variable, the diagnostic ability in terms of AUC was 0.850 (95% CI 0.797–0.894) in the meta-data cohort. Here, ADCYAP1 is linked to Alzheimer disease.