Pharmacological upregulation of PGC-1α expression restores neuronal morphogenesis in mitochondrial dysfunctional cerebral organoids (Inak et al., 2021), while a large number of studies have suggested that PGC-1α is a potential therapeutic target for neurodegenerative diseases (Panes et al., 2022). This evidence concerns the gene PPARGC1A and neurodegenerative disease.