In patients with Parkinson's disease (PD), the 14-3-3 expression was down-regulated in substantia nigra, and four isoforms of 14-3-3 (ε, γ, σ, and ζ) were colocalized with α-synuclein within Lewy bodies (Foote and Zhou, 2012). The gene discussed is YWHAQ; the disease is Parkinson disease.