TNF and osteoarthritis: During the development of osteoarthritis of the knee, IL-1 and TNF-α stimulate the synovium to promote the production and secretion of synovial cells and chondrocytes, including inflammatory transmitters such as MMP, which degrade the patient's articular cartilage proteoglycans and collagen and accelerate the production and secretion of synovial cells and chondrocytes disease [1].