The PI3K/Akt/FoxO1/mTORC1 axis of the Mammalian Target of Rapamycin (mTOR) C1 pathway, induced by IGF-1, is known to be an essential signaling pathway for the pathogenesis of acne (Melnik, 2018; Cong et al., 2019). The gene discussed is MTOR; the disease is acne.