ACE2 and viral infectious disease: The main findings of this study were as follows: (i) The characterization of the dynamics of viral infection in the Calabria region, (ii) the description of the geographic distribution of mutations identified in the sequenced viral genomes of patients from Calabria, (iii) the identification of mutations predictive of reduced binding to class I MHC and/or reduced recognition by T cells, and (iv) the characterization of the effects of the most common mutations on S protein surface accessibility and the strength of the Spike–ACE2 interaction.