Since previous studies demonstrated that elevated nuclear RNA export is a hallmark of breast cancer cells, in part due to upregulation of SRSF3 in HER2+ and triple negative breast cancers 39, our study suggests that YTHDC1 may act in concert with this mechanism to promote the expression of pro-metastatic genes such as SMAD3. Here, YTHDC1 is linked to triple-negative breast carcinoma.