YTHDC1 and breast cancer: Notably, YTHDC1 protein expression is significantly higher in tumors having a proteomic profile representing upregulation of collagen VI (k7) and endoplasmic reticulum-related proteins (k10), which are consistent with cells undergoing metastasis/EMT, compared to either normal cells or tumors with a basal-like breast cancer proteomic profile (k4) 32-34 (Figure S1A).