Moreover, the serum levels of sclerostin were higher in the selected OI patients with different gene mutations (n = 2 for WNT1, n = 1 for TMEM38B, n = 1 for FKBP10 and n = 2 for BMP1) than those in healthy controls as detected by sclerostin antibody. The gene discussed is SOST; the disease is osteogenesis imperfecta.