Moreover, meta-analysis of BMD-increasing SOST variants, rs7209826 (G-allele) and rs188810925 (A-allele), yield an 18% higher risk of myocardial infarction and/or coronary revascularization (OR = 1.18, 95% CI: 1.06-1.32, P = 0.03) and a 13% higher risk of self-reported angina and chronic stable heart diseases (OR = 1.10, 95%CI: 1.00-1.20, P = 0.04) 29. The gene discussed is SOST; the disease is angina pectoris.