Obviously, the aggravation of AA and atherosclerosis induced by therapeutic sclerostin antibody in Col1a2+/G610C.ApoE-/- mice were attenuated by pretreatment of exogenous loop2m, indicating that sclerostin loop2 rather than loop3 played an important role in the protective effect of sclerostin on cardiovascular system of OI mice. Here, APOE is linked to osteogenesis imperfecta.