In this study, it was demonstrated that sclerostin decreased the AA incidence, the maximum ex vivo diameters of aortic arches, thoracic aortas and suprarenal aortas, the ratio of atherosclerotic lesion area to total cross cryo-section area of aortic roots, and serum levels of inflammatory cytokines and chemokine in hSOSTki.Col1a2+/G610C.ApoE-/- mice with AngII infusion, which further validated the protective effect of sclerostin on the cardiovascular system of OI (Figure 8). Here, APOE is linked to osteogenesis imperfecta.