MEKi, ERKi and KRAS ablation strongly elevate protective autophagy flux via LKB1-AMPK-ULK1 axis, inhibition of which sensitizes tumor cells to KRAS signaling inhibition in PDAC, melanoma and CRC models 162, 188, 189, implying autophagy as a common surviving mechanism. The gene discussed is KRAS; the disease is neoplasm.