Keeping in mind that 1995 Gross H.J. et al. demonstrated that utilizing flow cytometry could in fact discriminate rare cancer cells from other cells in blood and bone marrow introducing the usage of CD45 and “multiple markers, each identified by a separate color of immunofluorescence (yellow and two shades of red) tri-fluorochromes” 49; at that time a remarkable achievement in flow cytometry. This evidence concerns the gene PTPRC and cancer.