To overcome shortcomings of EpCAM as used by CellSearchTM system and others, the detection error of isolation by size of epithelial tumour cells (ISET) due to size overlapping between CTCs (12 -35μm) and some monocytes /eosinophils (12-20μm) 46, a lot of attention was shifted to the modern nanoelectromechanical CTC chip (NELMEC) and believed that NELMEC can solve aforementioned problems because compare with tumour cells, lower membrane capacitance and higher cytoplasmic conductivity in leukocytes would give less observable movement in the impedance of the SiNG electrode 51. This evidence concerns the gene EPCAM and neoplasm.