Furthermore, when CF-KO mice were compared to WT controls, pathological cardiac hypertrophy post-MI was significantly reduced, as demonstrated by lower cardiomyocyte cross-sectional area (CSA) and hypertrophic marker gene (Nppa, Nppb, and Myh7) mRNA levels (Figure S4A and S4B). This evidence concerns the gene MYH7 and cardiac hypertrophy.