Brain natriuretic peptide/NT-proBNP is synthesized in response to increased end-diastolic wall stress, in the setting of increased intracardiac volumes and filling pressures, and acts to natriuresis, diuresis, vasodilatation, improved myocardial relaxation, and reduced myocardial fibrosis via binding to multiple NP receptors (12). Here, NPPB is linked to Myocardial fibrosis.