The increased expression of miR-320 in CMs led to deterioration of cardiac function through inhibiting Pleckstrin Homology Domain Containing M3 (PLEKHM3), whereas the decreased expression of miR-320 in CFs caused myocardial fibrosis via derepressing interferon-induced transmembrane protein 1 (IFITM1) (25). Here, PLEKHM3 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.