Indeed, DCs-restricted Irf8 deletion—mainly affecting CD103+ cDC1—was associated with reduced T cell infiltration and atherosclerotic lesion development (37) and, similarly, Batf3 depletion, leading to a significant decrease of CD103+ DCs within the aorta, reduced Th1 polarization and IFN-γ production, thus protecting from atherosclerosis (38). The gene discussed is MPPE1; the disease is atherosclerosis.