The generation of in vitro tolerogenic-DCs culture by maintaining a lower expression of co-stimulatory molecules to promote Treg skewing (101), together with the possibility of silencing co-stimulatory molecules or the NF-KB pathway (144), are under investigation in different auto-immune diseases, including type 1 diabetes treatment and rheumatoid arthritis (RA). Here, NFKB1 is linked to rheumatoid arthritis.