TNF and obesity due to melanocortin 4 receptor deficiency: In patients with obesity, reduced levels of miRNA were correlated to higher behaviors of LDL and total cholesterol, high expression of inflammation molecules [IL-6 and tumor necrosis factor-α (TNF-α)], liver macrophage infiltration, high cellular expression of V-rel reticuloendotheliosis viral oncogene homolog A (RELA), and STEAP family member 4 (STEAP4/STAMP2) (23).