HMGA2 and obesity due to melanocortin 4 receptor deficiency: Recent studies showed that HMGA2, a target gene of some miRNAs produced in adipocytes, which is a transcription factor that can regulate adipogenesis (60, 70, 72, 73), is upregulated in subjects with obesity and patients with diabetes (74) and correlated with increased body weight and body fat (75), whereas HMGA2 knockout mice have less fat, low-fat content, and are not susceptible to obesity-related diseases (76).