AGT and left ventricular hypertrophy: Mandraffino et al. (27) showed that, in EH, there are higher levels of two miRNAs (miRNA-221 and miRNA-222) involved in vascular remodeling and neo-angiogenesis processes, related to greater cardiac remodeling, and left ventricular hypertrophy; these miRNAs were also correlated with the inflammatory response depending upon excessive Ang-II and with increased production of oxygen-free radicals (ROS).