NFE2L2 and hydrops fetalis: At this level, miRNA-132 could act by inhibiting the expression of nuclear factor erythroid-2-related factor 2 (Nrf2), a pleiotropic protein, physiologically regulating the expression of several antioxidant genes and other cytoprotective enzymes, playing a key role in the maintenance of the functional integrity of cardiomyocytes and cardiac fibroblasts, and preventing maladaptive cardiac remodeling and HF (55).