The concentrations of SOD, MDA, and hs-CRP, IL-6 were increased in the serum of both groups A and B compared to group C. Serum concentrations of SOD, MDA, and HS-CRP were higher in group A compared to group B. It indicates that dapagliflozin combined with metoprolol sustained-release tablets can effectively improve cardiac function, inflammatory response, and oxidative stress response in myocardial infarction patients post-PCI. This evidence concerns the gene IL6 and myocardial infarction.