NPPB and myocardial ischemia: Myocardial ischemia and hypoxia can lead to increased myocardial tension and activation of excitatory neurohumoral factors and stimulate the generation of myocardial cells, leading to the increase in the level of NT-proBNP; the higher the level of serum NT-proBNP, the greater the myocardial ischemia area [26].