Angiotensin II (ANG II) is found to disrupt the E/I balance in HPC, particularly the perforant pathway-dentate gyrus (PP-DG) theta-gamma phase-amplitude coupling (PAC), leading to the anxiety-like behaviors of mice, which presumably contributes to the anxiety vulnerability in patients with hypertension (Gao et al., 2021). The gene discussed is AGT; the disease is hypertensive disorder.