RGS12 and Cerebral ischemia: In the scenario of cerebral ischemia, 40 Hz visual stimulation restores the density of spines in CA1, particularly the mature stubby-shaped spines, while increasing the expression of regulator of G-protein signaling 12 (RGS12) and boosting the LTP of CA3-CA1 synapses via the RGS12-N type voltage-gated calcium channel (N-VGCC) pathway.