PTGS1 and Anxiety: It is noteworthy that we found 40 Hz visual stimulation effective to inhibit the activation of cortical microglia, down-regulate HDAC3/COX1/PGE2/EP2 signaling, and rescue the anxiety-like behavior of animals, indicating that GENUS might be a powerful and non-invasive intervention to manipulate microglia immune response (Zhu et al., 2022).