KCNQ2 and epilepsy: Heteromeric Kv7.2/Kv7.3 channels concentrate at the AIS (Pan et al., 2006) and this AIS localization is critical for their function to suppress AP firing in hippocampal neurons (Shah et al., 2008), whereas multiple epilepsy mutations decrease their enrichment at the AIS (Chung et al., 2006; Cavaretta et al., 2014; Kim et al., 2018; Zhang et al., 2020) and disrupt their ability to inhibit neuronal intrinsic excitability (Cavaretta et al., 2014; Kim et al., 2018).