In a large number of animal models of cerebral ischemia or neuronal cell ischemia models, Zincchelator (Tuo et al., 2018), neuregulin-1 β (Zhang et al., 2018), tfp5 (Ji et al., 2017), and tat-Cdk5 CTM (Zhu et al., 2019) are found to have a neuroprotective effect through Cdk5 related pathways. Here, CDK5 is linked to brain ischemia.