ALDH1A1 and Alzheimer disease: Recent studies have found some new substrates and signaling pathways related to Cdk5 in AD, such asCdk5-Mcl-1axis (Nikhil and Shah, 2017), ALDH1A1 (Nikhil et al., 2019), miR-125b (Zhuang et al., 2020a), and miR-504-3p (Chen et al., 2022).