Research in exercise-related iron deficiency has transitioned from treatment-focused research that primarily addresses dietary iron intake and supplement effectiveness, to a more prevention-focused approach that has addressed causes of iron deficiency and the influence of the iron regulatory hormone, hepcidin, on iron homeostasis (Nemeth et al., 2004; Peeling et al., 2009; Ganz, 2011; Pasricha et al., 2011; Sim et al., 2019). The gene discussed is HAMP; the disease is Iron deficiency anemia.