Margaryan et al. (15) questioned whether DNA methylation status of IL1RN, RELA (p65) and NFKB1 (p50) genes may be relevant to IL-1β and IL-1Ra production and may be a possible contributory factor in the inflammatory pathogenesis of T2DM (1). Patel et al. (21) performed genotyping of neuropeptide Y (NPY) and IL-1β single nucleotide polymorphisms (SNPs). This evidence concerns the gene IL1RN and type 2 diabetes mellitus.