* sFasL exhibited proinflammatory effect and induced mRNA levels of caspase-1, NF-κB and IL-1β.* Did not assess the impact of different therapy (gliclazide/metformin) on activation status of neutrophils.* HC group were not perfectly age-matched with the T2DM group.* Small sample size. This evidence concerns the gene NFKB1 and type 2 diabetes mellitus.