ADIPOQ and obesity due to melanocortin 4 receptor deficiency: * Levels of adiponectin and IL-1β are significantly modulated during the development of overweight and T2DM* Adiponectin levels are correlated with several pro‐inflammatory cytokines including IL-1β and with clinical parameters of obesity and T2DM.* Did not mention if age and sex were matched in the T2DM and the HC group.