* IL-1β plasma levels are increased in T2DM patients (P = 0.038).* LPS stimulation increased release of IL-1β compared to unstimulated samples except female patients. LPS induced IL-1β production by PBMCs from HC and T2DM males (P = 0.01 and P = 0.03, respectively) and in HC females (P< 0.001). Here, IL1B is linked to type 2 diabetes mellitus.