* Freshly isolated neutrophils from T2DM group did not exhibit significant differences in mRNA expression of IL-1β gene as compared to HC group.* sFasL significantly increased mRNA levels of IL-1β in neutrophils from T2DM group.* Protein levels of IL-1β were not affected by the sFasL treatment (P>0.05). The gene discussed is IL1B; the disease is type 2 diabetes mellitus.