The increase in the maternal weight gain and improviment fetal weight distribution of hypothyroid rats may be associated not only with increased levels of free T3 and T4 but also with the action of kisspeptin on maternal pancreatic function, as exogenous kisspeptin increases in vivo and in vitro insulin secretion by pancreatic β-cells in rats, mice, humans, and non-human primates (63–67), and pharmacological blockade or in vivo genetic ablation of the Kiss1R receptor in β-cells of pregnant mice results in glucose intolerance and impaired insulin secretion (68). Here, KISS1 is linked to Glucose intolerance.