ATF4 and hypothyroidism: Since maternal hypothyroidism causes reticular stress in rat placenta (40), and in vitro and in vivo studies have demonstrated that Kp-10 administration blocks the occurrence of reticular stress in hypothalamic neuronal cells exposed to androgen (46), it was evaluated whether Kp-10 treatment would affect the expression of GRP78, CHOP and ATF4 in the placenta of rats with hypothyroidism.