NOS2 and hypothyroidism: Since fetal-placental development is influenced by immune mediators produced by the placenta, and considering that previous studies have shown that maternal hypothyroidism affects placental TNFα, MIF, and NOS2 expression in rats (36), the effect of daily treatment with Kp-10 on placental TNFα, IL-10, and IL-6 expression was evaluated in hypothyroid rats.