TGM2 and type 1 diabetes mellitus: Given the inflammatory status in T1D in the pancreas, we then questioned whether NOD islets would have an aberrant expression of Tgm2. To this end, we first evaluated transcriptional expression levels of Tgm2 in the islets of Langerhans of 6- and 10-week-old C57BL/6 and NOD mice.