Interestingly, this increase was only present at 10 weeks of age, suggesting that targeting native antigens leads to increased immune infiltration, driving cytokine production and increased ER stress, which then results in an increased TGM2 activity and deamidation of β-cell proteins, thus suggesting that deamidation is involved in the amplification rather than the initiation stage of T1D. This evidence concerns the gene TGM2 and type 1 diabetes mellitus.