In one consanguineous family with a homozygous c.797G>T nonsynonymous sequence variant in ENPP1, the father (Case 13, Table 2) had rickets but no history of GACI, whereas his son (Case 14, Table 2) presented with GACI in the first week of life and later exhibited hypophosphatemia (1). The gene discussed is ENPP1; the disease is hypophosphatemia.