In order to explore the association between TCF7L2 gene polymorphisms and GDM susceptibility in Wuhan, central China, we investigated seven SNPs (rs11196218, rs4506565, rs7895340, rs7901695, rs11196205, rs12243326, and rs290487), which have been suggested to be correlated with T2DM but were rarely studied or without consistent conclusions in GDM. The gene discussed is TCF7L2; the disease is type 2 diabetes mellitus.