The results showed that the mRNA expression of RORC was elevated in the T1D patients compared to the HCs (1.18 ± 1.12 vs. 0.69 ± 1.05, P=0.0423), and the mRNA expression of T-bet (0.66 ± 0.40 vs. 1.53 ± 1.21, P=0.0001), GATA3 (0.93 ± 0.30 vs. 1.57 ± 0.91, P=0.0015) and RORC (0.69 ± 1.05 vs. 1.37 ± 1.52, P=0.0040) was increased in the T2D patients. Here, RORC is linked to type 2 diabetes mellitus.