The mRNA expression levels of Tim-1 (1.89 ± 1.43 vs. 0.81 ± 0.47, P<0.0001) and Tim-4 (1.39 ± 1.02 vs. 0.84 ± 0.69, P=0.0454) in the T2D patients were significantly higher than those in the HCs. This evidence concerns the gene TIMD4 and type 2 diabetes mellitus.