TBX21 and type 1 diabetes mellitus: Second, the ratio of T-Bet/GATA3 expression was significantly increased in both T1D subgroups (0.78 ± 0.54 vs. 1.37 ± 1.10, P=0.014 and 0.78 ± 0.54 vs. 1.29 ± 0.63, P=0.039, respectively), and there was no significant difference between the two T1D subgroups (P>0.05) (Figure 3B).