As shown in Figure 1, compared to that in the HCs, the mRNA expression level of Tim-1 in the T1D patients was increased (0.81 ± 0.47 vs. 1.34 ± 1.01, P=0.0355), while the expression level of Tim-3 was decreased (1.55 ± 1.22 vs. 0.74 ± 0.41, P=0.0013). The gene discussed is HAVCR2; the disease is type 1 diabetes mellitus.