Downstream in the GH/IGF1 signaling there is an strong analogy between inhibiting the GHR in mice with BM001 (Figure 6B) and the inhibitory effect of the small molecule S3I-201 on STAT3 with the same cancer cells (61, 62): Both inhibitors resulted in tumor regression of MM231 xenografted mice. Here, GH1 is linked to neoplasm.