TNF and hematoma: The increase in CD36 expression in the perihematomal region is associated with faster hematoma clearance, and reduced CD36 expression increases the production of pro-inflammatory M1 macrophages/microglia mediators, such as TNF-α and IL-1β, thus inhibiting erythrophagocytosis and hematoma clearance (Fang et al., 2014; Derry et al., 2020).