Genetic variations in DLG2/PSD-93 have been implicated in various disorders, including schizophrenia (Walsh et al., 2008; Kirov et al., 2012; Fromer et al., 2014), intellectual disability (Reggiani et al., 2017), and ASD (Ruzzo et al., 2019), as well as neurodegenerative disorders, such as AD (Hondius et al., 2016; Lawingco et al., 2021; Prokopenko et al., 2022) and Parkinson’s disease (PD) (Foo et al., 2017; Wu et al., 2018; Zhao et al., 2020). The gene discussed is DLG2; the disease is Parkinson disease.