Studies using a large-scale genetic analysis of human patients have indicated that the disruption of the Dlg2 gene is closely associated with psychiatric disorders, including schizophrenia (Walsh et al., 2008; Kirov et al., 2012; Fromer et al., 2014; Sanders et al., 2022), intellectual disability (Reggiani et al., 2017), and autism spectrum disorder (ASD) in humans (Egger et al., 2014; Ruzzo et al., 2019). This evidence concerns the gene DLG2 and Intellectual disability.