Furthermore, a recent study employing longitudinal imaging combined with genetic analyses has demonstrated that single nucleotide polymorphisms (SNPs) in DLG2/PSD-93 are associated with structural asymmetry of subcortical regions, including putamen in patients with Alzheimer’s disease (AD) (Wachinger et al., 2018). The gene discussed is DLG2; the disease is early-onset autosomal dominant Alzheimer disease.