APP and hematoma: Moreover, the immunostaining images depicted that the optic density of MBP was remarkably decreased, while APP, a maker of damaged axons [15], was obviously increased around hematoma in mice post-ICH (Figures 4(e)–4(g)), whereas this effect was abolished with the addition of 5 mg/kg DPX, to some extent (Figures 4(e)–4(g)).