GPX4 and prostate cancer: Since IDOAMP showed a pronounced inhibitory effect on PCa, we then planned to study the involved mechanism of this inhibition on prostate cancers In this experiment, after treatment of PC3 cells with IDOAMP for 24 h, we tested the protein expression of biomarkers for apoptosis (cleaved-PARP), autophagy (LC3B-I/II), necroptosis/necrosis (HMBG1), and ferroptosis (GPX4) [17].