Since IDOAMP showed a pronounced inhibitory effect on PCa, we then planned to study the involved mechanism of this inhibition on prostate cancers In this experiment, after treatment of PC3 cells with IDOAMP for 24 h, we tested the protein expression of biomarkers for apoptosis (cleaved-PARP), autophagy (LC3B-I/II), necroptosis/necrosis (HMBG1), and ferroptosis (GPX4) [17]. This evidence concerns the gene GPX4 and Familial prostate cancer.