In this study, CD4+/CD8+T increased gradually after CSM-TACE, and TH1(IL-2, IFN-R, TNF-A) levels on the 5th day after CSM-TACE were significantly higher than the preoperative levels, which further demonstrated that the immune microenvironment of the body showed a trend of enhancing specific anti-tumor ability after CSM-TACE. The gene discussed is TNF; the disease is neoplasm.