Grade 3-4 AEs were secondary hypertension (n=2,6.1%), hand-foot syndrome (n=2,6.1%), nausea or Vomiting (n=2,6.1%), diarrhea (n=1,3.0%), sensory neurotoxicity (n=1,3.0%), decreased neutrophil count (n=3,9.1%), decreased white blood count (n=3,9.1%) and increased ALT/AST (n=1,3.0%). The gene discussed is GPT; the disease is hypertensive disorder.