After NKG2D(z) and NKG2D(bbz) CAR-T cells were co-cultured with target tumor cells for 96 h, NKG2D(bbz) CAR-T cells exhibited lower exhaustion and secreted more IL2 within 24 h than NKG2D(z) CAR-T cells. Here, KLRK1 is linked to neoplasm.