Additionally, HCV infection may also induce the depression with the secondary factors such as diabetes, insulin resistance, metabolic syndrome, heart disease, and inflammatory conditions like joint pain, arthritis, motor, and sensory neuropathies, serotonin deficiency, a corticotropin-releasing hormone which leads to more release of inhibitory neurotransmitters and finally results in the development of depression (65, 115, 128, 129). The gene discussed is CRH; the disease is major depressive disorder.