As proposed by Hanahan and Weinberg, S1P is involved in all features of cancer, including sustained proliferative signaling, the evasion of growth inhibitors, resistance to apoptosis, the achievement of uncontrolled replication, angiogenesis, the activation of invasion and metastasis, the reprogramming of energy metabolism, and the evasion of the immune response (78). The gene discussed is MBTPS1; the disease is cancer.