For example, research suggests that grade II or III IDH wild-type astrocytomas may harbor chromosomal +7/-10, epidermal growth factor receptor (EGFR) amplification, and/or telomerase reverse transcriptase promoter (TERT) alterations, with the same prognosis as GBMs (76). The gene discussed is EGFR; the disease is astrocytoma (excluding glioblastoma).