BBC3 and Miyoshi myopathy: Meanwhile, they showed almost no effect on the expression levels of HSP90, TNFRSF1A and PUMA, which suggests that NF-κB signaling pathway was not activated after treatment in U266 cells, indirectly supporting our hypothesis that NF-κB pathway-associated necroptosis might play a role in DHA/EPA/bortezomib-induced cell death in MM cells.