MLKL and cancer: The novel regulatory mechanisms of necroptosis found are not paradoxical with the canonical necroptosis: in RIPK3-expressing cancer cells, the necrosome-mediated canonical necroptotic pathway is activated through phosphorylation of MLKL, whereas in RIPK3-deficient cancer cells caspase-mediated MLKL cleavage may be the trigger to induce the cell death induction (Figure 8).