Although the results indicated that MPZL3 is highly expressed in the majority of tumors and can be regarded as an oncogene, a previous study demonstrated that MPZL3 is highly induced in the process of epidermal differentiation and downregulated in cutaneous squamous cell carcinoma (cSCC), which is similar to our finding that MPZL3 is downregulated in SKCM. This evidence concerns the gene MPZL3 and cutaneous squamous cell carcinoma.