Hallmarks such as TGF-β signaling, protein secretion, PI3K-AKT pathway, mitotic spindle, Kas signaling, IFN-α, IFN-γ, IL6-JAK-STAT3 signaling, IL2-STAT5 signaling, HEME metabolism, estrogen response, complement pathway, apoptosis pathway, androgen response were mostly positively correlated with MPZL3 expression in pan-cancers, while hallmarks such as xenobiotic metabolism, oxidative phosphorylation, Myc-targets, fatty-acid metabolism, E2F targets, DNA repair were mostly negative correlation with MPZL3 expression (Figure 5A). This evidence concerns the gene MYC and cancer.