Then we analyzed the relationship between 113 candidate genes and the prognosis of CRC, and obtained nine potential prognostic genes, including ABCD3, ABHD6, GAB1, MIER1, MYOCD, PDE8A, RPS6KA5, TPM1 and WDR78. And we speculate that the down-regulated circRNAs of these nine potential prognostic genes cause the low expression of their parental genes, which promote the progression of the CRC patients. This evidence concerns the gene RPS6KA5 and colorectal carcinoma.