Then we analyzed the relationship between 113 candidate genes and the prognosis of CRC, and obtained nine potential prognostic genes, including ABCD3, ABHD6, GAB1, MIER1, MYOCD, PDE8A, RPS6KA5, TPM1 and WDR78. And we speculate that the down-regulated circRNAs of these nine potential prognostic genes cause the low expression of their parental genes, which promote the progression of the CRC patients. The gene discussed is GAB1; the disease is colorectal carcinoma.